In the world of regenerative aesthetics, there are a lot of “latest-and-greatest” treatments that promise skin rejuvenation. But few hold up like polynucleotides. While I don’t post every transformation I see in practice (patient privacy always comes first), I can say confidently: the results I’ve seen using polynucleotide-based treatments are some of the most profound and long-lasting improvements in skin quality I’ve witnessed.
But what actually are polynucleotides and why are they becoming a go-to for integrative, evidence-backed skin repair?
What Are Polynucleotides (PNs)?
Polynucleotides are DNA fragments specifically purified from sources like salmon DNA that help your skin repair and regenerate at a cellular level. Unlike hyaluronic acid fillers that add immediate volume, PNs support your body’s natural healing mechanisms. Think of them less like a filler and more like fertilizer for your skin.
They don’t sculpt or reshape. Instead, they help build healthier, more resilient tissue from within encouraging the skin to bounce back stronger, smoother, and more radiant.
How Do They Work?
Polynucleotides stimulate key regenerative processes:
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Collagen and elastin production → Firmer, tighter skin
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Hydration optimization → Better skin barrier and dewy texture
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Inflammation reduction → Less redness, irritation, or reactivity
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Enhanced wound healing → Speeds up recovery from breakouts, procedures, or skin trauma
These benefits don’t happen overnight but that’s part of the appeal. The results are gradual, layered, and grounded in how your skin naturally heals itself over time.
What Makes One Polynucleotide Treatment Better Than Another?
Not all PNs are created equal. The source (how the DNA is purified), concentration, and formulation make a major difference in outcome. Some are simply better absorbed. Others stimulate more collagen. Quality control and clinical backing matter here—this is not a “just try whatever” kind of treatment.
Ideal for Treating:
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Dry, crepey skin or loss of elasticity
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Fine lines and texture changes
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Stressed or sensitized skin (post-acne or barrier damage)
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Scars and post-inflammatory pigmentation
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Dehydrated or dull complexions
If you’re looking for something that improves skin quality not just shape or volume this is one of the most intelligent options available right now.
Polynucleotides vs. Traditional Fillers
Let’s be clear: both have a place. But they work very differently.
Polynucleotides
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Improve texture, tone, and hydration
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Build collagen and elastin over time
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Repair skin from within
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Results take weeks but support long-term resilience
Traditional Fillers
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Provide immediate volume and structure
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Great for facial balancing or wrinkle filling
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Less impact on texture or skin health
I often combine the two in strategic protocols depending on your goals. But if your concern is poor skin quality not just contour PNs are unmatched.
What to Expect During Treatment
Every patient starts with a personalized consultation. Based on your goals, we use microneedling or microinjections to deliver the polynucleotides into the skin.
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Treatment time: ~30–45 minutes
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Downtime: Mild swelling or redness (24–48 hrs)
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Sessions needed: 2–3 spaced about a month apart
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Visible improvement: Usually within 4–6 weeks, and continues to build
Polynucleotides aren’t hype, but depends on how they are used. Lot's of overpromise for what they are not indicated for but they give your skin the support it needs to repair and rebuild itself. If you’ve been burned by quick fixes or just want better skin without extreme intervention, regenerative options like this are worth learning about.
I’ll continue to share insights from the science and the treatment room but as always, transformation takes time. The skin doesn’t lie when it’s given what it needs to thrive.