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dark spots, trust the leader

Professional depigmenting method that removes skin spots and prevents their reappearance for a short-and long-term outcome.

world's top method

more than one million patients around the world have already tried it. Thousands of professionals treat skin spots with cosmelan®.

high dermal safety

strict quality standards and numerous efficacy studies prove the method's safety and tolerance.

excellent clinical results

results that support the high effectiveness of the method in all skin spots.

high satisfaction from the patient

with visible results from the first week of treatment and in the long term.

what is cosmelan®?

cosmelan®, is the world's leading professional depigmentation method for treating the most severe and stubborn skin spots. Excellent results in the short and long term thanks to its unique dual action mechanism: corrective and regulatory. On the one hand, it eliminates the visible spot, but also acts on the source of the problem, regulating the overproduction of pigment to prevent its reappearance.

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phases of the treatment


phase 1: intense depigmentation

In this phase, the melanin deposits are removed and the renewal of the first layers of the skin is stimulated, improving its appearance and reducing the spot's intensity. 

application guideline:

The aesthetic professional applies the cosmelan 1 mask with an intensive depigmenting action.

After applying the mask, the customer will go home, allowing it to act for the time indicated by the professional, between 8 and 12 hours.


phase 2: continuous depigmentation

48-72 hours after removing the mask, it is necessary to complete the corrective action of the method and to regulate the overproduction of melanin. 

application guideline: 

We start with the daily application of cosmelan 2, together with melan recovery and melan 130 pigment control

Apply cosmelan 2 three times a day (morning, midday and night) followed by melan recoveryand melan 130 pigment control during daytime applications. This may vary per individual.


phase 3: regulating hyperpigmentation

In this phase we continue working on the root of the problem: the overproduction of melanin in a localised way. It should be regulated to avoid the hyperpigmentation's reappearance and unify the skin tone. 

application guideline: 

Apply cosmelan 2 morning and night followed by melan recovery and melan 130 pigment control during the day. In case of sun exposure, reapply UV protection every two hours.


phase 4: controlling reappearance 

During this phase, the treatment prevents the reappearance of the treated spots and the formation of new ones, for a longer-lasting result, as the tendency to develop spots represents an ongoing risk. 

application guideline: 

Apply cosmelan 2 at night followed by melan recovery. Apply melan 130 pigment controlduring the day and reapply in case of direct sun exposure.

mesoestetic® home care

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FAQs cosmelan®

The cosmelan® method is a topical treatment lasting approximately 6 months that combines a single salon session with the at-home treatment necessary to obtain optimum results.

at the clinic

A single salon session where the aesthetic professional applies the mask with an intensive depigmenting action.

at home

The treatment continues at home. Under the aesthetic professional's indications and recommendations, the patient must adhere to a regimen for the application of the cosmeceuticals complementary to the method, which will vary according to the phase and progress of the treatment.

The depigmentation process continues and we work on the source of the problem for a lasting result.

With cosmelan® we treat all types of spots of melanin origin, that is, spots originating due to melanin overproduction triggered by several factors (hormonal, genetic, post-acne, post-depilation factors, etc.) that worsen due to sun exposure. Therefore, cosmelan® is effective to treat spots such as: melasma, post-inflammatory hyperpigmentations (PIH), solar, senile lentigo and freckles.

Skin spots or dark spots are a very common problem, especially in women. It involves the darkening of the skin caused by an overproduction of pigment or melanin that unevenly accumulates in the skin. This overproduction is caused by an alteration of certain cellular mechanisms that lead to an excess of pigment.

There are different types of spots based on their origin and their distribution on the skin. It can appear due to several triggering factors, the most important being the result of solar radiation without protection. Other factors are also involved, such as a genetic predisposition, inflammatory conditions, hormonal changes and some photosensitising drugs (oral contraceptives, anti-inflammatory drugs, antibiotics, etc.).

It is a complex problem, and in many cases they are resistant to many medical-aesthetic treatments. In order to achieve an effective and long-lasting outcome and prevent a rebound, we must not only work on eliminating the accumulated pigment that causes the visible darkening, but also on treating the pathology's cellular origin, with the aim of stopping the overproduction of melanin and thus preventing the spots from reappearing.

cosmelan® can be used at any time of the year, though it is advisable to do it at times when sun exposure is not so intense or prolonged, such as the winter and autumn. In case you live in a hot region or apply the treatment in the summer, you must take greater care and use a very high sunscreen, such as melan 130 pigment control and avoid completely very intense and prolonged sun exposure.

The cosmelan® method consists of four phases which are necessary to achieve the target result. Intensive depigmentation in phase 1 and treatment for home use in phases 2, 3 and 4. The total duration of treatment is about 6 months, that can change based on the severity of the case.

The most significant change takes place a few weeks after applying the mask in clinic, it improves skin texture and spots decrease noticeably. This can give a misleading feeling of success. During this period melanin has been removed from the outermost skin layers, and therefore we see the spot much more faded and the skin smoother and softer, but the origin of the problem has not been controlled yet. The melanocyte, a cell where melanin is produced, is still uncontrolled and continues to produce pigment (melanin) in excess. To re-educate the melanocyte and control this overproduction, it is important to continue a home treatment with regulating action, so that the cell returns to a normal active state and therefore prevent spots from reappearing.

If you do not follow the home regimen, you are interrupting the treatment and will therefore not obtain the expected results. Not applying cosmelan 2 depigmenting cream with regulating action involves not regulating the melanocyte and, therefore, a persistent uncontrolled, excessive production of melanin. The spot will reappear as the skin layers are renewed, as melanin migrates to the surface making the spot increasingly evident.

Not using photoprotection, melan 130 pigment control, involves a very high risk that the spot returns, as skin is more sensitive and receptive to external aggressions during the treatment.

During at least the first three months of the method, it is not recommended to use any other type of minimally invasive treatment that can cause a skin lesion, as well as peels, microneedling, exfoliations, etc., as it can even cause repigmentation. It is advisable to use soothing and regenerating treatments both in clinic and at home in case it is needed.

In the last months where we reduce the application guidelines of cosmelan 2 only to the night, we can combine it with treatments that help prolong the results, such as melan tran3x concentrate and melan tran3x gel-cream.

As it is not an invasive treatment, it does not make you unable to fulfil your activities of daily living normally. Caution must be exerted when fulfilling some type of activities during the first days, a skin adaptation period after the cabin treatment. For instance, it is advisable to avoid bathing in swimming pools, prolonged sun exposure and activities that involve excessive sweating.

After an adequate professional treatment, excess pigmentation can be removed visibly. However, it is a dynamic process, where the imbalance forming them can cause their recurrence. Therefore, even if the spots are not seen, it is essential to apply a daily regulatory depigmentation treatment and photoprotection throughout the year to prevent repigmentation.

In case you are under the effect of any of the triggering factors for the appearance of spots (contraceptives, pregnancy, summer season, post-depilation, post-acne, post-peel, under photosensitising treatment, etc.), a daily treatment routine is essential, combining a depigmentation treatment, such as melan tran3x, with a high photoprotector such as melan 130 pigment control.

If used correctly and under the supervision of a professional, there should be no side effects. cosmelan® is a topical treatment, therefore minimally invasive, that does not prevent you from following your normal daily life. During the initial phase and following the treatment in consultation, the skin may become irritated or show redness. This is totally normal and expected, and it will disappear within a few days. During the home phase, it is common to experience slight peeling and sensitivity, which are symptoms that disappear when applying the home products recommended by the specialist.

cosmelan® is a depigmentation treatment; therefore, it is not indicated to treat active acne. If you would like to treat acne in its different phases of acneic and seborrhoeic skin, we recommend the acnelan medical treatment (active link to acnelan's consumer page). However, acne has an inflammatory component that can lead to the appearance of skin spots, known as PIH (Post-inflammatory Hyperpigmentation). cosmelan® is effective on this type of spots caused by acne, in all skin types and phototypes.

Both are depigmentation treatments that produce excellent results, but cosmelan® is an aesthetic treatment, whereas dermamelan® is a treatment that requires medical supervision and monitoring. The new dermamelan® is a new generation treatment that, thanks to the development of an unedited formula, has two patents that allow for a more comprehensive and effective action when treating the most severe and resistant spots. This innovation has led to a more efficient and convenient protocol with results after 4 months of treatment.