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In the evolving world of cosmetic treatments, botulinum toxin products stand as a cornerstone, offering revolutionary solutions for a variety of aesthetic and medical concerns. While Botox® has long been the household name synonymous with wrinkle reduction, the landscape has broadened, bringing forward new products like Dysport®, Xeomin®, Jeuveau™, and the recent addition, Daxxify. Each of these products presents unique formulations, ranging from Botox®, Dysport®, and Jeuveau™ with their accessory proteins, to the 'naked' neurotoxin Xeomin®, and Daxxify’s innovative peptide-stabilized formulation. These variations influence not just the efficacy and duration of the treatment, but also the body's response, potentially impacting long-term effectiveness and the risk of resistance. With FDA approvals encompassing a spectrum of applications from facial wrinkles to specific medical conditions, and varying durations and dosages, the decision to choose the right product has become more intricate than ever. I want to delve into the nuanced world of these neurotoxins, exploring their differences, applications, and the factors influencing their selection in both cosmetic and medical settings.

Formulation and Purity

  • Botox®, Dysport®, Jeuveau™: These contain accessory proteins along with the botulinum toxin. These proteins can play a role in how the body responds to the treatment, potentially impacting its effectiveness and the likelihood of developing resistance.
  • Xeomin®: It's a "naked" neurotoxin, meaning it lacks these complexing proteins. This might reduce the risk of antibody formation, potentially making it a good choice for long-term users.
  • Daxxify: Utilizes a peptide to stabilize the botulinum toxin, a unique approach that contributes to its longer duration of effect.

FDA-Approved Uses

  • Botox®: Known for its wide range of FDA-approved uses, including various facial wrinkles and medical conditions like chronic migraines and hyperhidrosis (excessive sweating).
  • Dysport®, Xeomin®, Jeuveau™: Approved for cosmetic uses, with specific indications that might slightly differ, such as the severity of wrinkles they're approved to treat.
  • Daxxify: Its approval is currently focused on glabellar lines, offering a more targeted option for this specific concern.

Duration of Effect

  • Botox®: The effects usually last for 3-4 months, making it a standard option for those seeking regular treatments.
  • Daxxify: Stands out with its "6-9 months duration", appealing to those seeking fewer treatments per year.*


  • Botox®: Typically recommended 20 units for glabellar lines.
  • Daxxify: Requires a higher minimum dose of 40 units for the same area, reflecting its potency and longer duration.

Time on Market

  • Botox®: A well-established product with a long track record since 2002, offering a sense of reliability and extensive clinical backing.
  • Daxxify: As a newer product (FDA-approved in 2022), it might appeal to those looking for the latest advancements in neurotoxin technology.


  • Daxxify: May be more expensive per unit but could offer cost savings in the long run due to its longer-lasting effects, requiring fewer treatments per year.
  • Botox®: While potentially cheaper per unit, it may require more frequent treatments.

We offer the same set price not matter the toxin. Learn more here

Choosing the Right Product

The choice between these products will depend on various factors, including:

  • Individual Patient Needs: Different responses to the formulations, considering factors like skin type, area of treatment, and history of botulinum toxin use.
  • Specific Area Being Treated: Some products may work better for certain areas or types of wrinkles.
  • Desired Duration of Effect: Preference for longer-lasting effects versus more frequent treatments.
  • Cost Considerations: Budget and willingness to pay for longer-lasting effects.
  • Physician’s Recommendation: Based on experience and understanding of each product’s nuances.

Important Note

While all these products are neuromodulators, they are not directly interchangeable. We must adjust dosing and treatment strategies based on the specific product used.

Always consult with a medical professional, plastic surgeon or a dermatologist to determine the best option for your individual needs and to understand the potential risks and benefits of each treatment.

*Disclaimer, results may vary from person to person.


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